Publications
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort
Alzheimer's & Dementia: Diagnosis, Assessment & Disease MonitoringAbstractIntroduction: Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a... -
Demirtaş M, Tornador C, Falcón C, López-Solà M, Hernández-Ribas R, Pujol J, Menchón JM, Ritter P, Cardoner N, Soriano-Mas C, Deco G
Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder
Human Brain MappingAbstractResting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the... -
Sánchez-Benavides G, Peña-Casanova J, Casals-Coll M, Gramunt N, Manero RM, Puig-Pijoan A, Aguilar M, Robles A, Antúnez C, Frank-García A, Fernández-Martínez M, Blesa R, NEURONORMA Study Team
One-Year Reference Norms of Cognitive Change in Spanish Old Adults: Data from the NEURONORMA Sample.
Archives of Clinical NeuropsychologyAbstractObjective: Serial cognitive assessments are useful for many purposes, such as monitoring cognitive decline or evaluating the result of an intervention. In order to determine if an observed change is... -
Molinuevo JL, Gramunt N, Gispert JD, Fauria K, Esteller M, Minguillon C, Sánchez-Benavides G, Huesa G, Morán S, Huesa G
The ALFA project: a research platform to identify early pathophysiological features of Alzheimer’s disease
Alzheimer's & Dementia: Translational Research & Clinical InterventionsAbstractIntroduction: The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project... -
Aparicio J, Carreño M, Bargalló N, Setoain X, Rubí S, Rumià J, Falcón C, Calvo A, Martí-Fuster B, Padilla N, Boget T, Pintor L, Donaire A
Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis
Neuroimage: ClinicalAbstractObjectives: Several studies using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) or diffusion tensor imaging (DTI) have found both temporal and extratemporal abnormalities in... -
Molinuevo JL, Cami J, Carné X, Carrillo MC, Georges J, Isaac MB, Khachaturian Z, Kim SYH, Morris JC, Pasquier F, Ritchie C, Sperling R, Karlawish J
Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit
Alzheimer's & DementiaAbstractAlzheimer's disease (AD) is among the most significant health care burdens. Disappointing results from clinical trials in late-stage AD persons combined with hopeful results from trials in persons... -
Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleo A, Blesa R, Gispert JD, Sanchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Haass C
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
EMBO Molecular MedicineAbstractTREM2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type-1 protein... -
Van Eldik LJ, Carrillo MC, Cole PE, Feuerbach D, Greenberg BD, Hendrix JA, Kennedy M, Kozauer N, Margolin RA, Molinuevo JL, Mueller R, Ransohoff RM, Wilcock DM, Bain L, Bales K
The roles of inflammation and immune mechanisms in Alzheimer's disease
Alzheimer's & Dementia: Translational Research & Clinical InterventionsAbstractThe Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune... -
Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, Jack CR Jr, Iwg & Amer Alzheimer's Assoc P
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
Alzheimer's & DementiaAbstractDuring the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries... -
Gramunt N, Sánchez-Benavides G, Buschke H, Dieguez-Vide F, Pena-Casanova J, Masramon X, Fauria K, Gispert JD, Molinuevo JL
The Memory Binding Test: Development of Two Alternate Forms into Spanish and Catalan
Journal of Alzheimer's DiseaseAbstractBackground: The Memory Binding Test (MBT) is emerging as a promising tool for the detection of subtle memory impairment suggestive of Alzheimer's disease (AD). For such a test to be widely accessed...
