Alzheimer's articles
Scientific articles published by the researchers of Barcelonaβeta Brain Research Center (BBRC), related to Alzheimer's disease, neuroimaging, memory and neurodegenerative diseases, among other fields.
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Sánchez-Benavides G, Iranzo A, Grau-Rivera O, Giraldo DM, Buongiorno M
Olfactory Dysfunction as a Clinical Marker of Early Glymphatic Failure in Neurodegenerative Diseases
DiagnosticsAbstractAn abnormal accumulation of misfolded proteins is a common feature shared by most neurodegenerative disorders. Olfactory dysfunction (OD) is common in the elderly population and is present in 90% of...
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Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ.
Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries
JAMA Netw OpenAbstractImportance: Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of APOE in AD varies with sex and ancestry. While the association of...
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Kuhn E, Klinger HM, Amariglio RE, Wagner M, Jessen F, Düzel E, Heneka MT, Chételat G, Rentz DM, Sperling RA, Ebenau JL, Butterbrod E, Van Der Flier WM, Sikkes SAM, Teunnissen CE, Van Harten AC, Van De Giessen EM, Rami L, Tort A, Sánchez Benavides G, Gifford KA, Van Hulle C, Buckley RF.
SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies
Alzheimer's & DementiaAbstractIntroduction: Specific features of subjective cognitive decline (SCD-plus) have been proposed to indicate an increased risk of preclinical Alzheimer's disease (AD). However, few studies have examined...
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Anastasi F, Fernández-Lebrero A, Ashton NJ, Ortiz-Romero P, Torres-Torronteras J, González-Escalante A, Milà-Alomà M, Contador J, García-Escobar G, Manero-Borràs RM, Navalpotro-Gómez I, Jiménez-Moyano E, Sahajan A, Hao Q, Zhang B, Jeromin A, Le Bastard N, Nadal A, Mousavi T, Kollmorgen G, Carboni M, Grau-Rivera O, Zetterberg H, Del Campo M, Blennow K, Puig-Pijoan A, Suárez-Calvet M.
A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Alzheimer's & DementiaAbstractIntroduction: Blood-based biomarkers for Alzheimer's disease (AD) have been widely studied, but direct comparisons of several biomarkers in clinical settings remain limited.
Methods: In this cross...
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Cacciaglia R, Falcón C, Benavides GS, Brugulat-Serrat A, Alomà MM, Calvet MS, Molinuevo JL, Fauria K, Minguillón C, Kollmorgen G, Quijano-Rubio C, Blennow K, Zetterberg H, Lorenzini L, Wink AM, Ingala S, Barkhof F, Ritchie CW, Gispert JD
Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer's continuum: Evidence across two independent cohorts
Alzheimer's & DementiaAbstractIntroduction: Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. We...
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Bolsewig K, Willemse EAJ, Sánchez-Juan P, Rábano A, Martínez M, Doecke JD, Bellomo G, Vermunt L, Alcolea D, Halbgebauer S, In 't Veld S, Mattsson-Carlgren N, Veverova K, Fowler CJ, Boonkamp L, Koel-Simmelink M, Hussainali Z, Ruiters DN, Gaetani L, Toja A, Fortea J, Pijnenburg Y, Lemstra AW, van der Flier WM, Hort J, Otto M, Hansson O, Parnetti L, Masters CL, Lleó A, Teunissen CE, Del Campo Milán M.
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment
Nature CommunicationsAbstractDOPA Decarboxylase (DDC) has been proposed as a cerebrospinal fluid (CSF) biomarker with increased concentrations in Lewy body disorders (LBDs) and highest levels in patients receiving dopaminergic...
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Jin J, Chen J, Cavaillès C, Yaffe K, Winer J, Stankeviciute L, Lucey BP, Zhou X, Gao S, Peng D, Leng Y.
Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Sleep disturbances are associated with Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid...
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Genius P, Calle ML, Rodríguez-Fernández B, Minguillon C, Cacciaglia R, Garrido-Martin D, Esteller M, Navarro A, Gispert JD, Vilor-Tejedor N.
Compositional brain scores capture Alzheimer's disease-specific structural brain patterns along the disease continuum
Alzheimer's & DementiaAbstractIntroduction: Traditional multivariate methods for neuroimaging studies overlook the interdependent relationship between brain features. This study addresses this gap by analyzing relative brain...
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Biel D, Suárez-Calvet M, Dewenter A, Steward A, Roemer SN, Dehsarvi A, Zhu Z, Pescoller J, Frontzkowski L, Kreuzer A, Haass C, Schöll M, Brendel M, Franzmeie
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease
EMBO Molecular MedicineAbstractIn Alzheimer's disease (AD), Aβ triggers p-tau secretion, which drives tau aggregation. Therefore, it is critical to characterize modulators of Aβ-related p-tau increases which may alter AD...
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García-Lezana T, Bobowicz M, Frid S, Rutherford M, Recuero M, Riklund K, Cabrelles A, Rygusik M, Fromont L, Francischello R, Neri E, Capella S, Navarro A, Prior F, Bona J, Nicolas P, Starmans MPA, Lekadir K, Rambla J.
New implementation of data standards for AI in oncology: Experience from the EuCanImage project
GigaScienceAbstractBackground: An unprecedented amount of personal health data, with the potential to revolutionize precision medicine, is generated at health care institutions worldwide. The exploitation of such data...
