Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Kuhn E, Klinger HM, Amariglio RE, Wagner M, Jessen F, Düzel E, Heneka MT, Chételat G, Rentz DM, Sperling RA, Ebenau JL, Butterbrod E, Van Der Flier WM, Sikkes SAM, Teunnissen CE, Van Harten AC, Van De Giessen EM, Rami L, Tort A, Sánchez Benavides G, Gifford KA, Van Hulle C, Buckley RF.
SCD-plus features and AD biomarkers in cognitively unimpaired samples: A meta-analytic approach for nine cohort studies
Alzheimer's & DementiaAbstractIntroduction: Specific features of subjective cognitive decline (SCD-plus) have been proposed to indicate an increased risk of preclinical Alzheimer's disease (AD). However, few studies have examined...
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Anastasi F, Fernández-Lebrero A, Ashton NJ, Ortiz-Romero P, Torres-Torronteras J, González-Escalante A, Milà-Alomà M, Contador J, García-Escobar G, Manero-Borràs RM, Navalpotro-Gómez I, Jiménez-Moyano E, Sahajan A, Hao Q, Zhang B, Jeromin A, Le Bastard N, Nadal A, Mousavi T, Kollmorgen G, Carboni M, Grau-Rivera O, Zetterberg H, Del Campo M, Blennow K, Puig-Pijoan A, Suárez-Calvet M.
A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Alzheimer's & DementiaAbstractIntroduction: Blood-based biomarkers for Alzheimer's disease (AD) have been widely studied, but direct comparisons of several biomarkers in clinical settings remain limited.
Methods: In this cross...
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Cacciaglia R, Falcón C, Benavides GS, Brugulat-Serrat A, Alomà MM, Calvet MS, Molinuevo JL, Fauria K, Minguillón C, Kollmorgen G, Quijano-Rubio C, Blennow K, Zetterberg H, Lorenzini L, Wink AM, Ingala S, Barkhof F, Ritchie CW, Gispert JD
Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer's continuum: Evidence across two independent cohorts
Alzheimer's & DementiaAbstractIntroduction: Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. We...
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Bolsewig K, Willemse EAJ, Sánchez-Juan P, Rábano A, Martínez M, Doecke JD, Bellomo G, Vermunt L, Alcolea D, Halbgebauer S, In 't Veld S, Mattsson-Carlgren N, Veverova K, Fowler CJ, Boonkamp L, Koel-Simmelink M, Hussainali Z, Ruiters DN, Gaetani L, Toja A, Fortea J, Pijnenburg Y, Lemstra AW, van der Flier WM, Hort J, Otto M, Hansson O, Parnetti L, Masters CL, Lleó A, Teunissen CE, Del Campo Milán M.
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment
Nature CommunicationsAbstractDOPA Decarboxylase (DDC) has been proposed as a cerebrospinal fluid (CSF) biomarker with increased concentrations in Lewy body disorders (LBDs) and highest levels in patients receiving dopaminergic...
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Jin J, Chen J, Cavaillès C, Yaffe K, Winer J, Stankeviciute L, Lucey BP, Zhou X, Gao S, Peng D, Leng Y.
Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease
Alzheimer's & DementiaAbstractIntroduction: Sleep disturbances are associated with Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid...
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Genius P, Calle ML, Rodríguez-Fernández B, Minguillon C, Cacciaglia R, Garrido-Martin D, Esteller M, Navarro A, Gispert JD, Vilor-Tejedor N.
Compositional brain scores capture Alzheimer's disease-specific structural brain patterns along the disease continuum
Alzheimer's & DementiaAbstractIntroduction: Traditional multivariate methods for neuroimaging studies overlook the interdependent relationship between brain features. This study addresses this gap by analyzing relative brain...
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Biel D, Suárez-Calvet M, Dewenter A, Steward A, Roemer SN, Dehsarvi A, Zhu Z, Pescoller J, Frontzkowski L, Kreuzer A, Haass C, Schöll M, Brendel M, Franzmeie
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease
EMBO Molecular MedicineAbstractIn Alzheimer's disease (AD), Aβ triggers p-tau secretion, which drives tau aggregation. Therefore, it is critical to characterize modulators of Aβ-related p-tau increases which may alter AD...
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Aye S, Johansson G, Hock C, Lannfelt L, Sims JR, Blennow K, Frederiksen KS, Graff C, Molinuevo JL, Scheltens P, Palmqvist S, Schöll M, Wimo A, Kivipelto M, Handels R, Frölich L, Zilka N, Tolar M, Johannsen P, Jönsson L, Winblad B
Point of view: Challenges in implementation of new immunotherapies for Alzheimer's disease
The journal of prevention of Alzheimer's DiseaseAbstractThe advancement of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a...
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Argiris G, Akinci M, Peña-Gómez C, Palpatzis E, Garcia-Prat M, Shekari M, Blennow K, Zetterberg H, Kollmorgen G, Quijano-Rubio C, Ashton NJ, Karikari TK, Brinkmalm-Westman A, Lantero-Rodriguez J, Fauria K, Sánchez-Benavides G, Grau-Rivera O, Suárez-Calvet M, Arenaza-Urquijo EM.
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease
Alzheimer's Research & TherapyAbstractBackground: Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer's disease (AD) core biomarkers, have improved the...
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Canals-Gispert L, Cañas-Martínez A, Huesa G, Suárez-Calvet Alomà M, Milà-Alomà M, Arenaza-Urquijo E, Cirillo D, Dimech AS, Iulita MF, Martinkova JN, Tartaglia MC, Quevenco FC, Chadha AS, Sánchez-Benavides G, Minguillón C, Ferretti MT, Fauria K, Brugulat-Serrat A
Impact of gender on the willingness to participate in clinical trials and undergo related procedures in individuals from an Alzheimer's prevention research cohort
Alzheimer's Research & TherapyAbstractBackground: Although there is growing evidence of the association between gender and early diagnosis of preclinical Alzheimer's disease, little attention has been given to the enrolment ratio of men...
