Publicacions
Articles científics publicats pels investigadors del Barcelonaβeta Brain Research Center (BBRC), relacionats amb la malaltia d'Alzheimer, la neuroimatge, la memòria i les malalties neurodegeneratives, entre altres camps.
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Pahlke S, Kahale LA, Mahinrad S, Sousa-Pinto B, Vieira RJ, McAteer MB, Claessen T, Contador J, Hofmann A, Kuchenbecker LA, Machado LS, Warmenhoven N, Yakoub Y, Palmqvist S, Schindler SE, Teunissen C, Whitson HE, Zetterberg H, Edelmayer R, Tampi MP
Blood-based biomarkers for detecting Alzheimer's disease pathology in cognitively impaired individuals within specialized care settings: A systematic review and meta-analysis
Alzheimer's & DementiaAbstractBackground: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively...
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Gregory S, Bridgeman K, Darwin H, Barbato M, Booi L, Brugulat Serrat A, Chadha AS, Farina FR, Jenkins N, Jutila OI, Low A, Marongiu R, Naci L, Pulford P, Ritchie CW, Ritchie K, Udeh-Momoh C, Watermeyer T, Welstead M, Muniz-Terrera G
Associations of estrogen with modifiable and non-modifiable risk factors for dementia: A narrative review
Alzheimer's & DementiaAbstractFemale sex is associated with higher incidence and risk of dementia. Estrogen may represent one important mechanism contributing to the increase in incidence rates. In this review, we synthesize...
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Pieperhoff L, Lorenzini L, Mastenbroek S, Tranfa M, Shekari M, Wink AM, Wolz R, Grootoonk S, Ritchie C, Boada M, Marquié M, van der Flier W, Vandenberghe R, Hanseeuw BJ, Martínez-Lage P, Payoux P, Visser PJ, Schöll M, Frisoni GB, Stephens A, Buckley C, Farrar G, Jessen F, Grau-Rivera O, Gispert JD, García DV, Mutsaerts H, Barkhof F, Collij LE
Amyloid PET predicts atrophy in older adults without dementia: Results from the AMYPAD Prognostic & Natural History study
Neuroimage: ClinicalAbstractThe impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer's disease (AD), and its interaction with risk factors like sex and APOE-ε4 carriership, remains unclear. In...
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Tranfa M, Pieperhoff L, Pontillo G, Luckett ES, Collij LE, Oliveira TG, Tesi N, Vilor-Tejedor N, Altmann A, Roccatagliata L, Pardini M, Holstege H, Reinders M, Payoux P, Martinez-Lage P, Ritchie CW, Waldman A, Wardlaw JM, Gispert JD, Salvadó G, Brunetti A, Mutsaerts HJMM, Wink AM, Barkhof F, Lorenzini L
Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes
Alzheimer's Research & TherapyAbstractBackground: The accumulation of amyloid-β1-42 (Aβ1-42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer's disease (AD) has led to a biological definition...
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Sciancalepore F, Salemme S, Valletta M, Blasi MT, Remoli G, Zamboni G, Vanacore N, Canevelli M
Frailty and the brain: A narrative review of functional and pathological correlates
Ageing Research ReviewsAbstractFrailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with...
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López-Martos D, Suárez-Calvet M, Milà-Alomà M, Gispert JD, Salvadó G, Brugulat-Serrat A, Shekari M, Minguillon C, Zetterberg H, Blennow K, Grau-Rivera O, Sánchez-Benavides G; ALFA study.
Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease
NeurologyAbstractBackground and objectives: Addressing the association between early-changing Alzheimer disease (AD) biomarkers and cognition is essential for characterizing preclinical AD. However, few studies have...
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Vilor-Tejedor N, Rodrigo A, Genius P, Rodríguez-Fernández B, Anastasi F, Pelkmans W, Navarro A, Adams HH, Wisse L, Gispert JD, Evans TE; ADNI.
Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment
Neuroimage: ClinicalAbstractThe hippocampus, crucial in cognitive aging and Alzheimer's disease (AD), shows early atrophy during disease progression. This study investigated 5-year trajectories of hippocampal volumes across AD...
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Olvera-Rojas M, Solis-Urra P, Fernandez-Gamez B, Coca-Pulido A, Triviño-Ibáñez EM, Zeng X, Oberlin LE, Gispert JD, Erickson KI, Gómez-Río M, Karikari TK, Ortega FB, Esteban-Cornejo I.
Classification accuracies of plasma ptau217 vs. ptau217/Aβ1-42 for brain Aβ pathology in cognitively normal older adults
GeroscienceAbstractAlzheimer´s Disease (AD) and neurodegenerative blood-based biomarkers (BBMs) are transitioning from research settings to clinical practice, where accurate interpretation is critical for their...
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Perneczky R, Quevenco FC, Hendrix J, Epelbaum S, Teunissen C, van der Flier WM, Suárez-Calvet M, Shi J, Mielke MM, Iwatsubo T, Palmqvist S, Hansson O
How can Alzheimer's disease blood-based biomarkers reach clinical practice?
Alzheimer's & DementiaAbstractIntroduction: Alzheimer's disease (AD) diagnosis has been based largely on clinical symptoms, despite their limited sensitivity and specificity. Biomarker use was proposed to support a more accurate...
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Milà-Alomà M, Van Hulle C, Brugulat-Serrat A, Casals Brodú M, González-Escalante A, Sánchez-Benavides G, Shekari M, Castro-Aldrete L, Minguillón C, Novakova Martinkova J, Tartaglia MC, Quijano-Rubio C, Kollmorgen G, Schumacher Dimech A, Cirillo D, Quevenco FC, Iulita MF, Fauria K, Gispert JD, Ferretti MT, Santuccione Chadha A, Johnson SC, Suárez-Calvet M; ALFA study.
Sex differences in Alzheimer's disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals
Alzheimer's Research & TherapyAbstractBackground: Alzheimer's disease (AD) exhibits sex differences in prevalence, symptoms and risk factors. Understanding the effect of sex in AD cerebrospinal fluid (CSF) biomarkers and their association...
